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KMID : 0606920110190030357
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Biomolecules & Therapeutics
2011 Volume.19 No. 3 p.357 ~ p.363
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Enhanced Local Anesthetic Efficacy of Bioadhesive Ropivacaine Gels
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Cho Cheong-Weon
Choi Jun-Shik
Shin Sang-Chul
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Abstract
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In relieving local pains, ropivacaine has been widely used. In case of their application such as ointments and creams, it is diffi cult to expect their effects for a signifi cant period of time, because they are easily removed by wetting, movement and contacting. Therefore, the new formulations that have suitable bioadhesion were needed to enhance local anesthetic effects. The effect of drug concentration and temperature on drug release was studied from the prepared 1.5% Carboxymethyl cellulose (CMC) (150 MC) gels using synthetic cellulose membrane at 37 ± 0.5°C. As the drug concentration and temperature increased, the drug release increased. A linear relationship was observed between the logarithm of the permeability coeffi cient and the reciprocal temperature. The activation energy of drug permeation was 3.16 kcal/mol for a 1.5% loading dose. To increase the skin permeation of ropivacaine from CMC gel, enhancers such as saturated and unsaturated fatty acids, pyrrolidones, propylene glycol derivatives, glycerides, and non-ionic surfactants were incorporated into the ropivacaine-CMC gels. Among the enhancers used, polyoxyethylene 2-oleyl ether showed the highest enhancing effects. For the effi cacy study, the anesthetic action of the formulated ropivacaine gel containing an enhancer and vasoconstrictor was evaluated with the tail-fl ick analgesimeter. According to the rat tail-fl ick test, 1.5% drug gels containing polyoxyethylene 2-oleyl ether and tetrahydrozoline showed the best prolonged local analgesic effects. In conclusion, the enhanced local anesthetic gels containing penetration enhancer and vasoconstrictor could be developed using the bioadhesive polymer.
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KEYWORD
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Local anesthetics, Ropivacaine, Bioahhesive, Gel, Penetration enhancer, Tail fl ick anesthetic test
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